cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
Identifieur interne : 001568 ( Main/Exploration ); précédent : 001567; suivant : 001569cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
Auteurs : Lukas Stanczuk [Royaume-Uni] ; Ines Martinez-Corral [Royaume-Uni] ; Maria H. Ulvmar [Suède] ; Yang Zhang [Suède] ; Bàrbara Lavi A [Suède] ; Marcus Fruttiger [Royaume-Uni] ; Ralf H. Adams [Allemagne] ; Dieter Saur [Allemagne] ; Christer Betsholtz [Suède] ; Sagrario Ortega [Espagne] ; Kari Alitalo [Finlande] ; Mariona Graupera [Espagne] ; Taija M Kinen [Royaume-Uni]Source :
- Cell reports [ 2211-1247 ] ; 2015.
Abstract
Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.
DOI: 10.1016/j.celrep.2015.02.026
PubMed: 25772358
Affiliations:
- Allemagne, Espagne, Finlande, Royaume-Uni, Suède
- Angleterre, Bade-Wurtemberg, Catalogne, Communauté de Madrid, District de Karlsruhe, District de Münster, East Middle Sweden, Grand Londres, Rhénanie-du-Nord-Westphalie, Svealand, Uusimaa
- Barcelone, Heidelberg, Helsinki, Londres, Madrid, Munich, Münster, Uppsala
- University College de Londres, Université d'Helsinki, Université d'Uppsala, Université technique de Munich
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Adams</name><affiliation wicri:level="3"><nlm:affiliation>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Saur, Dieter" sort="Saur, Dieter" uniqKey="Saur D" first="Dieter" last="Saur">Dieter Saur</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name><affiliation wicri:level="1"><nlm:affiliation>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:affiliation>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Graupera, Mariona" sort="Graupera, Mariona" uniqKey="Graupera M" first="Mariona" last="Graupera">Mariona Graupera</name><affiliation wicri:level="1"><nlm:affiliation>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@igp.uu.se.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25772358</idno><idno type="pmid">25772358</idno><idno type="doi">10.1016/j.celrep.2015.02.026</idno><idno type="wicri:Area/PubMed/Corpus">000F87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F87</idno><idno type="wicri:Area/PubMed/Curation">000F87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F87</idno><idno type="wicri:Area/PubMed/Checkpoint">000F87</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F87</idno><idno type="wicri:Area/Ncbi/Merge">007141</idno><idno type="wicri:Area/Ncbi/Curation">007141</idno><idno type="wicri:Area/Ncbi/Checkpoint">007141</idno><idno type="wicri:Area/Main/Merge">001570</idno><idno type="wicri:Area/Main/Curation">001568</idno><idno type="wicri:Area/Main/Exploration">001568</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.</title><author><name sortKey="Stanczuk, Lukas" sort="Stanczuk, Lukas" uniqKey="Stanczuk L" first="Lukas" last="Stanczuk">Lukas Stanczuk</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ulvmar, Maria H" sort="Ulvmar, Maria H" uniqKey="Ulvmar M" first="Maria H" last="Ulvmar">Maria H. Ulvmar</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Zhang, Yang" sort="Zhang, Yang" uniqKey="Zhang Y" first="Yang" last="Zhang">Yang Zhang</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lavi A, Barbara" sort="Lavi A, Barbara" uniqKey="Lavi A B" first="Bàrbara" last="Lavi A">Bàrbara Lavi A</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Fruttiger, Marcus" sort="Fruttiger, Marcus" uniqKey="Fruttiger M" first="Marcus" last="Fruttiger">Marcus Fruttiger</name><affiliation wicri:level="4"><nlm:affiliation>UCL Institute of Ophthalmology, University College London (UCL), 11-43 Bath Street, London EC1V 9EL, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London (UCL), 11-43 Bath Street, London EC1V 9EL</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H" last="Adams">Ralf H. Adams</name><affiliation wicri:level="3"><nlm:affiliation>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Saur, Dieter" sort="Saur, Dieter" uniqKey="Saur D" first="Dieter" last="Saur">Dieter Saur</name><affiliation wicri:level="4"><nlm:affiliation>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name><affiliation wicri:level="1"><nlm:affiliation>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:affiliation>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Graupera, Mariona" sort="Graupera, Mariona" uniqKey="Graupera M" first="Mariona" last="Graupera">Mariona Graupera</name><affiliation wicri:level="1"><nlm:affiliation>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation wicri:level="4"><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@igp.uu.se.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Finlande</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>District de Münster</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Rhénanie-du-Nord-Westphalie</li><li>Svealand</li><li>Uusimaa</li></region><settlement><li>Barcelone</li><li>Heidelberg</li><li>Helsinki</li><li>Londres</li><li>Madrid</li><li>Munich</li><li>Münster</li><li>Uppsala</li></settlement><orgName><li>University College de Londres</li><li>Université d'Helsinki</li><li>Université d'Uppsala</li><li>Université technique de Munich</li></orgName></list><tree><country name="Royaume-Uni"><region name="Svealand"><name sortKey="Stanczuk, Lukas" sort="Stanczuk, Lukas" uniqKey="Stanczuk L" first="Lukas" last="Stanczuk">Lukas Stanczuk</name></region><name sortKey="Fruttiger, Marcus" sort="Fruttiger, Marcus" uniqKey="Fruttiger M" first="Marcus" last="Fruttiger">Marcus Fruttiger</name><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name></country><country name="Suède"><region name="Svealand"><name sortKey="Ulvmar, Maria H" sort="Ulvmar, Maria H" uniqKey="Ulvmar M" first="Maria H" last="Ulvmar">Maria H. Ulvmar</name></region><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name><name sortKey="Lavi A, Barbara" sort="Lavi A, Barbara" uniqKey="Lavi A B" first="Bàrbara" last="Lavi A">Bàrbara Lavi A</name><name sortKey="Zhang, Yang" sort="Zhang, Yang" uniqKey="Zhang Y" first="Yang" last="Zhang">Yang Zhang</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H" last="Adams">Ralf H. Adams</name></region><name sortKey="Saur, Dieter" sort="Saur, Dieter" uniqKey="Saur D" first="Dieter" last="Saur">Dieter Saur</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name></region><name sortKey="Graupera, Mariona" sort="Graupera, Mariona" uniqKey="Graupera M" first="Mariona" last="Graupera">Mariona Graupera</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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